The real enemy of Pope Boniface VIII was the leader of France in the 1300's, King Philip the Fair, who sent his henchman William of Nogaret to exact punishment on this saintly Pope by breaking entrance into his papal quarters in the Vatican, then striking the Pope with a sacrilegious blow on the face. 

Shortly thereafter, within a month, this pope died from this fatal blow thus transferring the papacy to Avignon, France for the next seventy years. This was the end of the Middle Ages and the inception of troubles